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Histamine Enzyme - Diamine Oxidase - 60 Capsules, Non GMO, Gluten Free, Soy Free

Diamine Oxidase for Digestive Health | Histamine Intolerance | Food Sensitivities | Leaky Gut

  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
  • May Reduce the Effects of Histamine Reactions to Wine*

Histamine Enzyme is a patented enzyme formula containing Diamine Oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. Histamine Enzyme does not manage or address antibody-related or IgE-related food allergies.*

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation. The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as  sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of  histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.

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Does Not Contain: Wheat, gluten, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.

All Bright Path Wellness, Inc. Formulas Meet or Exceed cGMP Quality Standards.

*These statements have not been evaluated by the Food and Drug Administration. The dietary supplements offered by Bright Path Wellness, Inc are not intended to diagnose, treat, cure, or prevent any disease or other medical condition.

Histamine Enzyme - Diamine Oxidase, Hist DAO, Leaky Gut, Histamine Intolerance



Customer Reviews

Based on 7 reviews
Back-up plan

I use several 20,000 dose capsules to move my body back into status when having symptoms; sometimes it is enough to correct the problem without needing an additional antihistamine.

The staff/company is great to work with, too!

Great Product

I have had a lot more freedom to eat without the coughing and inflammation that are often accompanied by eating a number of foods. It has improved my quality of life!


This product allows me more freedom in what I eat. I was eating a low histamine diet and still taking Allegra daily for chronic hives. I now take one of these pills anytime I am eating a food that I suspect might make me react and have only had to take Allegra once every couple of weeks. It’s truly given me my life back!




I have only used the DAO three times when I have strayed from a low histamine diet and am happy to say I had no allergic reaction from the food and am giving the DAO the credit. I will continue to use it with the hope that it will allow me to have a more varied diet.